Pancreatic Polypeptide, rat

CAS No. 90419-12-8

Pancreatic Polypeptide, rat ( Rat pancreatic polypeptide )

Catalog No. M29743 CAS No. 90419-12-8

Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cells of the islets of Langerhans.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 972 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote

Biological Information

  • Product Name
    Pancreatic Polypeptide, rat
  • Note
    Research use only, not for human use.
  • Brief Description
    Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cells of the islets of Langerhans.
  • Description
    Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cells of the islets of Langerhans.(In Vitro):Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca2+)i levels in BRIN BD11 cells at 1 μM.(In Vivo):Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice.
  • Synonyms
    Rat pancreatic polypeptide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    NPYR4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    90419-12-8
  • Formula Weight
    4398.9
  • Molecular Formula
    C195H298N58O57S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Khan D, et al. Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochim Biophys Acta. 2017 Apr;1861(4):749-758.
molnova catalog
related products
  • Ilicic acid

    Ilicic acid is a natural product of Laggera, Asteraceae. The catalog number is T4802 and the CAS number is 4586-68-9. Ilicic acid can be used as a reference standard.

  • Ac9-25

    N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.

  • Bombykol

    Bombykol is an insect sex pheromone that is produced as a sex attractant for the females of Bombyx mori.